| 2. Jornada | 07.02.2022 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 4. Jornada | 14.02.2022 | Managua FC | - | H&H Export Sébaco | 3:2 | ||||
| 9. Jornada | 09.03.2022 | H&H Export Sébaco | - | Real Madriz | 1:1 | ||||
| 12. Jornada | 03.04.2022 | H&H Export Sébaco | - | Club Deportivo Ocotal | 4:1 |  |
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| 13. Jornada | 06.04.2022 | H&H Export Sébaco | - | Managua FC | 2:0 | ||||
| 17. Jornada | 29.04.2022 | Diriangén FC | - | H&H Export Sébaco | 8:0 | ||||
| 18. Jornada | 02.05.2022 | Real Madriz | - | H&H Export Sébaco | 0:0 |
Nicaragua