| 1. Jornada | 23.07.2021 | PFC Beroe | - | Lokomotiv Sofia | 1:0 |  |
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| 2. Jornada | 01.08.2021 | Lokomotiv Sofia | - | Lokomotiv Plovdiv | 1:0 | |
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| 3. Jornada | 06.08.2021 | CSKA 1948 Sofia | - | Lokomotiv Sofia | 1:1 | ||||
| 5. Jornada | 21.08.2021 | PFC Ludogorets Razgrad | - | Lokomotiv Sofia | 5:0 | ||||
| 6. Jornada | 27.08.2021 | Arda Kardzhali | - | Lokomotiv Sofia | 1:1 | ||||
| 7. Jornada | 10.09.2021 | Lokomotiv Sofia | - | Pirin Blagoevgrad | 2:1 | |
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| 8. Jornada | 18.09.2021 | Cherno More Varna | - | Lokomotiv Sofia | 1:1 | ||||
| 9. Jornada | 27.09.2021 | Lokomotiv Sofia | - | Slavia Sofia | 1:0 | ||||
| 10. Jornada | 02.10.2021 | Botev Vratsa | - | Lokomotiv Sofia | 2:2 | ||||
| 11. Jornada | 16.10.2021 | Lokomotiv Sofia | - | Levski Sofia | 1:2 | ||||
| 12. Jornada | 22.10.2021 | Tsarsko Selo Sofia | - | Lokomotiv Sofia | 2:0 | ||||
| 15. Jornada | 21.11.2021 | Lokomotiv Plovdiv | - | Lokomotiv Sofia | 2:1 |  |
Argelia