| 1. Jornada | 14.08.2021 | Everton | - | Southampton | 3:1 | ||||
| 2. Jornada | 22.08.2021 | Southampton | - | Manchester United | 1:1 |  |
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| 3. Jornada | 28.08.2021 | Newcastle United | - | Southampton | 2:2 | |
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| 4. Jornada | 11.09.2021 | Southampton | - | West Ham United | 0:0 | ||||
| 6. Jornada | 26.09.2021 | Southampton | - | Wolverhampton Wanderers | 0:1 | ||||
| 7. Jornada | 02.10.2021 | Chelsea | - | Southampton | 3:1 | |
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| 8. Jornada | 16.10.2021 | Southampton | - | Leeds United | 1:0 | ||||
| 17. Jornada | 15.12.2021 | Crystal Palace | - | Southampton | 2:2 | ||||
| 26. Jornada | 19.02.2022 | Southampton | - | Everton | 2:0 | ||||
| 27. Jornada | 25.02.2022 | Southampton | - | Norwich City | 2:0 | ||||
| 21. Jornada | 10.03.2022 | Southampton | - | Newcastle United | 1:2 | ||||
| 38. Jornada | 22.05.2022 | Leicester City | - | Southampton | 4:1 |
Malí