| 1. Jornada | 06.08.2022 | Tottenham Hotspur | - | Southampton | 4:1 | ||||
| 2. Jornada | 13.08.2022 | Southampton | - | Leeds United | 2:2 | ||||
| 3. Jornada | 20.08.2022 | Leicester City | - | Southampton | 1:2 | ||||
| 4. Jornada | 27.08.2022 | Southampton | - | Manchester United | 0:1 | ||||
| 5. Jornada | 30.08.2022 | Southampton | - | Chelsea | 2:1 | ||||
| 6. Jornada | 03.09.2022 | Wolverhampton Wanderers | - | Southampton | 1:0 | ||||
| 8. Jornada | 16.09.2022 | Aston Villa | - | Southampton | 1:0 | ||||
| 10. Jornada | 08.10.2022 | Manchester City | - | Southampton | 4:0 | ||||
| 12. Jornada | 19.10.2022 | Bournemouth | - | Southampton | 0:1 | ||||
| 14. Jornada | 29.10.2022 | Crystal Palace | - | Southampton | 1:0 | ||||
| 17. Jornada | 26.12.2022 | Southampton | - | Brighton & Hove Albion | 1:3 | ||||
| 21. Jornada | 21.01.2023 | Southampton | - | Aston Villa | 0:1 | ||||
| 30. Jornada | 08.04.2023 | Southampton | - | Manchester City | 1:4 | ||||
| 31. Jornada | 15.04.2023 | Southampton | - | Crystal Palace | 0:2 | ||||
| 34. Jornada | 30.04.2023 | Newcastle United | - | Southampton | 3:1 | ||||
| 36. Jornada | 13.05.2023 | Southampton | - | Fulham FC | 0:2 |  |
Malí