| 1. Jornada | 21.08.2021 | Paphos FC | - | APOEL Nikosia | 4:0 |  |
|||
| 2. Jornada | 13.09.2021 | APOEL Nikosia | - | Olympiacos Nikosia | 0:1 | ||||
| 3. Jornada | 19.09.2021 | Apollon Limassol | - | APOEL Nikosia | 2:1 | ||||
| 4. Jornada | 27.09.2021 | APOEL Nikosia | - | PAEEK | 1:0 | ||||
| 5. Jornada | 03.10.2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 | ||||
| 6. Jornada | 18.10.2021 | APOEL Nikosia | - | Ethnikos Achna | 2:1 | ||||
| 12. Jornada | 05.12.2021 | APOEL Nikosia | - | Paphos FC | 1:1 | ||||
| 13. Jornada | 12.12.2021 | Olympiacos Nikosia | - | APOEL Nikosia | 1:1 | ||||
| 14. Jornada | 18.12.2021 | APOEL Nikosia | - | Apollon Limassol | 1:1 | ||||
| 11. Jornada | 26.12.2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | |
|||
| 17. Jornada | 15.01.2022 | Ethnikos Achna | - | APOEL Nikosia | 0:3 | |
|||
| 19. Jornada | 30.01.2022 | APOEL Nikosia | - | Doxa Katokopias | 2:0 | |
|||
| 20. Jornada | 06.02.2022 | AEL Limassol | - | APOEL Nikosia | 2:3 | ||||
| 15. Jornada | 09.02.2022 | PAEEK | - | APOEL Nikosia | 1:3 | ||||
| 21. Jornada | 14.02.2022 | APOEL Nikosia | - | AEK Larnaca | 1:0 | ||||
| 16. Jornada | 17.02.2022 | APOEL Nikosia | - | Anorthosis Famagusta | 0:2 |
Georgia