| 5. Jornada | 06.02.2022 | Alianza | - | Luis Ángel Firpo | 0:0 | ||||
| 6. Jornada | 10.02.2022 | Santa Tecla FC | - | Alianza | 2:3 | ||||
| 7. Jornada | 13.02.2022 | Alianza | - | Platense Zacatecoluca | 1:0 | ||||
| 8. Jornada | 20.02.2022 | Municipal Limeño | - | Alianza | 0:0 | ||||
| 9. Jornada | 23.02.2022 | Once Municipal | - | Alianza | 1:2 | ||||
| 10. Jornada | 27.02.2022 | Alianza | - | Atlético Marte | 3:2 | ||||
| 4. Jornada | 03.03.2022 | Alianza | - | FAS | 1:1 |  |
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| 11. Jornada | 06.03.2022 | Alianza | - | CD Águila | 0:0 | |
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| 12. Jornada | 13.03.2022 | Isidro Metapán | - | Alianza | 0:0 | ||||
| 13. Jornada | 20.03.2022 | Alianza | - | Jocoro FC | 2:1 | ||||
| 15. Jornada | 03.04.2022 | FAS | - | Alianza | 1:3 | |
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| 16. Jornada | 10.04.2022 | Luis Ángel Firpo | - | Alianza | 0:1 | |
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| 18. Jornada | 17.04.2022 | Platense Zacatecoluca | - | Alianza | 0:1 |
El Salvador