| 8. Jornada | 10.09.2021 | Spartak Subotica | - | TSC Bačka Topola | 0:0 | ||||
| 9. Jornada | 18.09.2021 | FK Čukarički | - | Spartak Subotica | 2:1 | ||||
| 10. Jornada | 22.09.2021 | Spartak Subotica | - | Proleter Novi Sad | 1:2 | ||||
| 11. Jornada | 26.09.2021 | Partizan | - | Spartak Subotica | 5:0 | ||||
| 12. Jornada | 02.10.2021 | Spartak Subotica | - | FK Voždovac | 0:4 | ||||
| 13. Jornada | 15.10.2021 | FK Novi Pazar | - | Spartak Subotica | 0:1 | ||||
| 14. Jornada | 23.10.2021 | Spartak Subotica | - | FK Metalac | 2:0 | ||||
| 17. Jornada | 21.11.2021 | Spartak Subotica | - | FK Radnički 1923 | 1:1 | ||||
| 18. Jornada | 28.11.2021 | Crvena Zvezda | - | Spartak Subotica | 3:0 | ||||
| 20. Jornada | 14.12.2021 | Vojvodina | - | Spartak Subotica | 2:3 | ||||
| 21. Jornada | 18.12.2021 | FK Napredak | - | Spartak Subotica | 1:0 | ||||
| 22. Jornada | 14.02.2022 | Spartak Subotica | - | Radnik Surdulica | 0:2 | ||||
| 23. Jornada | 19.02.2022 | TSC Bačka Topola | - | Spartak Subotica | 2:1 | ||||
| 26. Jornada | 06.03.2022 | Spartak Subotica | - | Partizan | 0:1 | ||||
| 28. Jornada | 20.03.2022 | Spartak Subotica | - | FK Novi Pazar | 1:2 | ||||
| 29. Jornada | 02.04.2022 | FK Metalac | - | Spartak Subotica | 2:0 |
Serbia