| 1. Jornada | 07.08.2021 | SC Cham | - | FC Sion II | 2:1 | ||||
| 2. Jornada | 18.08.2021 | FC Sion II | - | FC Black Stars Basel | 0:0 | ||||
| 3. Jornada | 21.08.2021 | FC Bavois | - | FC Sion II | 3:1 | ||||
| 4. Jornada | 28.08.2021 | FC Sion II | - | FC Stade Nyonnais | 1:1 | ||||
| 6. Jornada | 11.09.2021 | FC Sion II | - | BSC Young Boys II | 2:0 |  |
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| 14. Jornada | 06.11.2021 | SC Brühl | - | FC Sion II | 0:1 | ||||
| 16. Jornada | 20.11.2021 | FC Sion II | - | SC Cham | 3:4 | ||||
| 21. Jornada | 06.03.2022 | BSC Young Boys II | - | FC Sion II | 3:0 | ||||
| 22. Jornada | 12.03.2022 | FC Sion II | - | FC Chiasso | 0:1 | ||||
| 23. Jornada | 20.03.2022 | FC Biel/Bienne | - | FC Sion II | 1:3 | |
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| 27. Jornada | 09.04.2022 | FC Sion II | - | FC Zürich II | 2:1 | ||||
| 28. Jornada | 16.04.2022 | FC Breitenrain Bern | - | FC Sion II | 2:0 | ||||
| 29. Jornada | 23.04.2022 | FC Sion II | - | SC Brühl | 2:4 | |
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| 30. Jornada | 30.04.2022 | SC YF/Juventus Zürich | - | FC Sion II | 3:4 | |
Irlanda