| 1. Jornada | 25.07.2010 | Deportivo Guadalajara | - | Puebla FC | 0:0 | ||||
| 2. Jornada | 01.08.2010 | Puebla FC | - | Club San Luis | 2:1 |  |
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| 3. Jornada | 09.08.2010 | Estudiantes Tecos | - | Puebla FC | 1:3 |  |
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| 4. Jornada | 15.08.2010 | Puebla FC | - | Atlante | 1:1 | |
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| 5. Jornada | 22.08.2010 | Pumas UNAM | - | Puebla FC | 4:1 | ||||
| 6. Jornada | 29.08.2010 | Puebla FC | - | CF Pachuca | 3:1 | ||||
| 7. Jornada | 12.09.2010 | Jaguares Chiapas | - | Puebla FC | 4:0 | |
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| 8. Jornada | 19.09.2010 | Puebla FC | - | UANL Tigres | 1:3 | |
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| 9. Jornada | 26.09.2010 | Atlas Guadalajara | - | Puebla FC | 1:0 | |
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| 10. Jornada | 03.10.2010 | Puebla FC | - | Gallos Blancos (old) | 2:0 | |
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| 11. Jornada | 09.10.2010 | Club Necaxa | - | Puebla FC | 1:0 | ||||
| 12. Jornada | 17.10.2010 | Puebla FC | - | CF América | 2:2 | ||||
| 13. Jornada | 24.10.2010 | Deportivo Toluca | - | Puebla FC | 2:1 | |
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| 15. Jornada | 31.10.2010 | Cruz Azul | - | Puebla FC | 1:0 | ||||
| 16. Jornada | 07.11.2010 | Puebla FC | - | CF Monterrey | 2:0 | |
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| 17. Jornada | 14.11.2010 | Monarcas Morelia | - | Puebla FC | 3:3 | |
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Uruguay