| 1. Jornada | 07.11.2021 | AE Kifisias | - | Panathinaikos II | 2:0 | ||||
| 5. Jornada | 27.11.2021 | Panathinaikos II | - | AE Karaiskakis | 2:2 | ||||
| 6. Jornada | 04.12.2021 | Ergotelis | - | Panathinaikos II | 1:0 | ||||
| 7. Jornada | 12.12.2021 | Panathinaikos II | - | Asteras Vlachioti | 2:0 | ||||
| 8. Jornada | 15.12.2021 | Diagoras FC | - | Panathinaikos II | 1:2 | ||||
| 9. Jornada | 18.12.2021 | Panathinaikos II | - | PAE Chania | 0:2 |  |
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| 10. Jornada | 29.12.2021 | APS Zakynthos | - | Panathinaikos II | 0:1 | ||||
| 12. Jornada | 08.01.2022 | GS Kallithea | - | Panathinaikos II | 1:0 | ||||
| 14. Jornada | 15.01.2022 | Irodotos | - | Panathinaikos II | 0:0 | ||||
| 11. Jornada | 19.01.2022 | Panathinaikos II | - | OFI Ierapetra | 3:1 | ||||
| 15. Jornada | 23.01.2022 | Panathinaikos II | - | Levadiakos | 1:3 | ||||
| 19. Jornada | 16.02.2022 | AEK Athen II | - | Panathinaikos II | 0:1 | ||||
| 20. Jornada | 20.02.2022 | Panathinaikos II | - | PS Kalamata | 1:2 | ||||
| 22. Jornada | 05.03.2022 | AE Karaiskakis | - | Panathinaikos II | 1:1 | |
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| 23. Jornada | 09.03.2022 | Panathinaikos II | - | Ergotelis | 0:0 | ||||
| 24. Jornada | 12.03.2022 | Asteras Vlachioti | - | Panathinaikos II | 3:1 | ||||
| 25. Jornada | 19.03.2022 | Panathinaikos II | - | Diagoras FC | 3:0 |
Grecia