| 5. Jornada | 03.10.2021 | Panetolikos | - | AEK Athen | 1:3 | ||||
| 6. Jornada | 17.10.2021 | Panetolikos | - | OFI Heraklion | 1:2 | ||||
| 7. Jornada | 24.10.2021 | Aris Saloniki | - | Panetolikos | 5:1 | ||||
| 8. Jornada | 30.10.2021 | Panetolikos | - | Olympiacos | 1:2 |  |
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| 9. Jornada | 06.11.2021 | PAS Giannina | - | Panetolikos | 3:0 | ||||
| 10. Jornada | 21.11.2021 | Panetolikos | - | Apollon Smyrnis | 1:0 | |
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| 11. Jornada | 28.11.2021 | Panathinaikos | - | Panetolikos | 2:0 | ||||
| 12. Jornada | 04.12.2021 | Volos NFC | - | Panetolikos | 1:2 | |
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| 13. Jornada | 11.12.2021 | Panetolikos | - | Ionikos Nikea | 2:2 | ||||
| 14. Jornada | 14.12.2021 | Asteras Tripolis | - | Panetolikos | 1:0 | ||||
| 15. Jornada | 18.12.2021 | Panetolikos | - | Atromitos | 2:1 | ||||
| 16. Jornada | 12.01.2022 | PAOK Saloniki | - | Panetolikos | 2:0 | |
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| 18. Jornada | 16.01.2022 | AEK Athen | - | Panetolikos | 1:2 | ||||
| 19. Jornada | 22.01.2022 | OFI Heraklion | - | Panetolikos | 2:4 | ||||
| 20. Jornada | 30.01.2022 | Panetolikos | - | Aris Saloniki | 0:2 | ||||
| 22. Jornada | 05.02.2022 | Panetolikos | - | PAS Giannina | 0:1 |
Grecia
Alemania