| 5. Jornada | 21.08.2021 | Puebla FC [Sub 16] | - | Club Tijuana [Sub 16] | 3:0 |  |
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| 6. Jornada | 28.08.2021 | CF Pachuca [Sub 16] | - | Club Tijuana [Sub 16] | 1:0 | ||||
| 12. Jornada | 09.10.2021 | Club Tijuana [Sub 16] | - | Puebla FC [Sub 16] | 3:1 | ||||
| 13. Jornada | 16.10.2021 | CF América [Sub 16] | - | Club Tijuana [Sub 16] | 4:2 |  |
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| 15. Jornada | 30.10.2021 | Club Tijuana [Sub 16] | - | Gallos Blancos [Sub 16] | 3:2 | |
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| 16. Jornada | 06.11.2021 | FC Juárez [Sub 16] | - | Club Tijuana [Sub 16] | 1:3 | |
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| 18. Jornada | 20.11.2021 | Club Tijuana [Sub 16] | - | Cruz Azul [Sub 16] | 0:0 |
México