| 1. Jornada | 20.01.2022 | Honduras Progreso | - | Motagua | 2:1 | ||||
| 2. Jornada | 23.01.2022 | Honduras Progreso | - | Lobos UPNFM | 1:2 | ||||
| 3. Jornada | 06.02.2022 | Olimpia | - | Honduras Progreso | 3:0 | ||||
| 4. Jornada | 10.02.2022 | Real Sociedad | - | Honduras Progreso | 4:2 | ||||
| 5. Jornada | 13.02.2022 | Honduras Progreso | - | Marathón | 2:1 | ||||
| 6. Jornada | 20.02.2022 | Vida | - | Honduras Progreso | 0:2 | ||||
| 7. Jornada | 27.02.2022 | Real España | - | Honduras Progreso | 3:0 | ||||
| 8. Jornada | 04.03.2022 | Honduras Progreso | - | Victoria | 2:1 |  |
|||
| 9. Jornada | 07.03.2022 | Platense | - | Honduras Progreso | 0:0 | ||||
| 10. Jornada | 13.03.2022 | Honduras Progreso | - | Olimpia | 1:3 | ||||
| 11. Jornada | 20.03.2022 | Lobos UPNFM | - | Honduras Progreso | 2:2 | ||||
| 12. Jornada | 03.04.2022 | Honduras Progreso | - | Real Sociedad | 0:1 | ||||
| 13. Jornada | 07.04.2022 | Marathón | - | Honduras Progreso | 1:1 | ||||
| 14. Jornada | 10.04.2022 | Honduras Progreso | - | Vida | 3:1 | |
|||
| 15. Jornada | 14.04.2022 | Victoria | - | Honduras Progreso | 2:2 | ||||
| 16. Jornada | 21.04.2022 | Motagua | - | Honduras Progreso | 3:2 | |
|||
| 18. Jornada | 01.05.2022 | Honduras Progreso | - | Platense | 3:1 | |
Colombia