| 8. Jornada | 14.09.2008 | Club San Luis | - | CF América | 1:2 | ||||
| 9. Jornada | 21.09.2008 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
| 10. Jornada | 28.09.2008 | Club San Luis | - | Puebla FC | 1:1 | ||||
| 12. Jornada | 12.10.2008 | Club San Luis | - | Deportivo Guadalajara | 0:0 |  |
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| 13. Jornada | 18.10.2008 | UAG Tecos | - | Club San Luis | 5:2 | ||||
| 14. Jornada | 26.10.2008 | Club San Luis | - | CF Monterrey | 2:0 | ||||
| 15. Jornada | 02.11.2008 | Club Necaxa | - | Club San Luis | 1:1 |  |
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| 16. Jornada | 09.11.2008 | Club San Luis | - | Santos Laguna | 2:2 | ||||
| 17. Jornada | 16.11.2008 | Deportivo Toluca | - | Club San Luis | 1:0 |
México