| 1. Jornada | 25.07.2021 | FC Fastav Zlín | - | Slavia Praga | 0:1 | ||||
| 2. Jornada | 30.07.2021 | FK Teplice | - | Slavia Praga | 1:3 | ||||
| 4. Jornada | 14.08.2021 | FK Mladá Boleslav | - | Slavia Praga | 0:2 | ||||
| 5. Jornada | 22.08.2021 | Slavia Praga | - | Baník Ostrava | 4:0 | ||||
| 6. Jornada | 29.08.2021 | MFK Karviná | - | Slavia Praga | 3:3 | ||||
| 11. Jornada | 16.10.2021 | Slavia Praga | - | Slovan Liberec | 3:1 | ||||
| 12. Jornada | 24.10.2021 | Dynamo České Budějovice | - | Slavia Praga | 2:2 | ||||
| 22. Jornada | 20.02.2022 | Slavia Praga | - | Bohemians Praha 1905 | 1:0 | ||||
| 24. Jornada | 06.03.2022 | Slavia Praga | - | Sparta Praga | 2:0 | ||||
| 25. Jornada | 13.03.2022 | Slovan Liberec | - | Slavia Praga | 1:0 | ||||
| 26. Jornada | 20.03.2022 | Slavia Praga | - | Dynamo České Budějovice | 1:0 | ||||
| 27. Jornada | 03.04.2022 | Viktoria Plzeň | - | Slavia Praga | 1:1 | ||||
| 29. Jornada | 17.04.2022 | FK Jablonec | - | Slavia Praga | 1:2 |  |
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| 30. Jornada | 20.04.2022 | Slavia Praga | - | FC Fastav Zlín | 3:0 |
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