| 1. Jornada | 17.07.2010 | Spartak Trnava | - | FK Senica | 3:0 |  |
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| 5. Jornada | 14.08.2010 | FK Senica | - | MFK Košice | 1:0 |  |
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| 7. Jornada | 29.08.2010 | FK Senica | - | Slovan Bratislava | 3:2 | |
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| 12. Jornada | 16.10.2010 | FK Senica | - | Spartak Trnava | 1:2 | |
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| 14. Jornada | 30.10.2010 | MFK Dubnica | - | FK Senica | 0:1 | |
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| 17. Jornada | 19.11.2010 | FK Senica | - | MŠK Žilina | 2:1 | |
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| 18. Jornada | 27.11.2010 | Slovan Bratislava | - | FK Senica | 2:2 | |
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| 19. Jornada | 26.02.2011 | FK Senica | - | FK Dukla Banská Bystrica | 3:0 | |
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| 20. Jornada | 04.03.2011 | FC Nitra | - | FK Senica | 0:5 | |
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| 21. Jornada | 12.03.2011 | FK Senica | - | MFK Ružomberok | 4:0 | |
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| 23. Jornada | 18.03.2011 | FK Senica | - | Spartak Trnava | 4:0 | |
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| 26. Jornada | 15.04.2011 | FC DAC 1904 | - | FK Senica | 0:3 | |
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| 27. Jornada | 22.04.2011 | FK Senica | - | MFK Košice | 1:1 | |
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| 30. Jornada | 11.05.2011 | FK Dukla Banská Bystrica | - | FK Senica | 3:2 | |
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| 31. Jornada | 14.05.2011 | FK Senica | - | FC Nitra | 3:2 | |
República Checa