| 1. Jornada | 21.03.2021 | Blooming | - | CD Guabirá | 0:1 |  |
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| 3. Jornada | 03.04.2021 | Bolívar | - | Blooming | 2:0 | |
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| 4. Jornada | 10.04.2021 | Blooming | - | Club Aurora | 1:0 |  |
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| 5. Jornada | 25.04.2021 | Real Tomayapo | - | Blooming | 2:1 | ||||
| 6. Jornada | 04.05.2021 | Blooming | - | Club San José | 4:0 | ||||
| 7. Jornada | 07.05.2021 | Real Santa Cruz | - | Blooming | 1:0 | ||||
| 17. Jornada | 22.08.2021 | Independiente Petrolero | - | Blooming | 3:0 | ||||
| 18. Jornada | 15.09.2021 | Blooming | - | Bolívar | 2:2 | |
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| 19. Jornada | 18.09.2021 | Club Aurora | - | Blooming | 2:0 | ||||
| 20. Jornada | 22.09.2021 | Blooming | - | Real Tomayapo | 0:1 | ||||
| 21. Jornada | 25.09.2021 | Club San José | - | Blooming | 1:2 | ||||
| 22. Jornada | 18.10.2021 | Blooming | - | Real Santa Cruz | 3:1 | |
Bolivia