| 17. Jornada | 21.08.2021 | Club San José | - | Always Ready | 0:4 | ||||
| 23. Jornada | 22.10.2021 | Club San José | - | Club Aurora | 1:4 | ||||
| 26. Jornada | 22.11.2021 | Club San José | - | Real Santa Cruz | 1:2 | ||||
| 27. Jornada | 26.11.2021 | Nacional Potosí | - | Club San José | 7:1 | ||||
| 28. Jornada | 30.11.2021 | Club San José | - | Oriente Petrolero | 0:2 | ||||
| 29. Jornada | 05.12.2021 | The Strongest | - | Club San José | 2:0 |
Bolivia