| 1. Jornada | 27.07.2008 | CF América | - | Santos Laguna | 3:2 | ||||
| 2. Jornada | 04.08.2008 | Santos Laguna | - | Pumas UNAM | 1:1 | ||||
| 8. Jornada | 14.09.2008 | Santos Laguna | - | Club Necaxa | 1:1 | ||||
| 9. Jornada | 21.09.2008 | Cruz Azul | - | Santos Laguna | 1:1 | ||||
| 10. Jornada | 28.09.2008 | Deportivo Toluca | - | Santos Laguna | 2:1 | ||||
| 14. Jornada | 26.10.2008 | Atlas Guadalajara | - | Santos Laguna | 2:1 |  |
México