| 6. Jornada | 28.08.2021 | CF América [Sub 16] | - | FC Juárez [Sub 16] | 3:0 | ||||
| 7. Jornada | 04.09.2021 | Club Tijuana [Sub 16] | - | CF América [Sub 16] | 2:1 | ||||
| 8. Jornada | 11.09.2021 | Deportivo Toluca [Sub 16] | - | CF América [Sub 16] | 1:0 |  |
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| 9. Jornada | 18.09.2021 | CF América [Sub 16] | - | Cruz Azul [Sub 16] | 1:2 | ||||
| 15. Jornada | 30.10.2021 | CF América [Sub 16] | - | Deportivo Toluca [Sub 16] | 0:3 | ||||
| 17. Jornada | 13.11.2021 | CF América [Sub 16] | - | Puebla FC [Sub 16] | 1:1 | ||||
| 18. Jornada | 20.11.2021 | FC Juárez [Sub 16] | - | CF América [Sub 16] | 2:0 |
México