| 7. Jornada | 02.09.2012 | Santos Laguna | - | UANL Tigres | 3:1 | ||||
| 9. Jornada | 23.09.2012 | Santos Laguna | - | Jaguares Chiapas | 0:0 | ||||
| 10. Jornada | 01.10.2012 | Atlante | - | Santos Laguna | 1:3 | ||||
| 11. Jornada | 04.10.2012 | Santos Laguna | - | Atlas Guadalajara | 2:1 |  |
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| 12. Jornada | 07.10.2012 | Gallos Blancos (old) | - | Santos Laguna | 1:1 | ||||
| 13. Jornada | 14.10.2012 | Santos Laguna | - | Club Tijuana | 2:2 | ||||
| 14. Jornada | 21.10.2012 | Deportivo Toluca | - | Santos Laguna | 4:1 | |
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| 16. Jornada | 03.11.2012 | Santos Laguna | - | Cruz Azul | 2:1 |
México
