| 4. Jornada | 04.02.2021 | Montevideo Wanderers | - | Boston River | 2:2 | ||||
| 5. Jornada | 07.02.2021 | Boston River | - | Peñarol | 1:2 |  |
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| 6. Jornada | 11.02.2021 | River Plate | - | Boston River | 3:1 | ||||
| 8. Jornada | 19.02.2021 | Plaza Colonia | - | Boston River | 3:0 | ||||
| 9. Jornada | 23.02.2021 | Boston River | - | Progreso | 2:3 | ||||
| 10. Jornada | 28.02.2021 | Fénix | - | Boston River | 2:1 | ||||
| 14. Jornada | 25.03.2021 | Nacional | - | Boston River | 1:2 | ||||
| 15. Jornada | 29.03.2021 | Boston River | - | Liverpool | 1:0 |
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