| 1. Jornada | 22.07.2018 | Atenas | - | Defensor Sporting | 2:5 |  |
|||
| 2. Jornada | 28.07.2018 | Defensor Sporting | - | Danubio | 1:2 | |
|||
| 3. Jornada | 05.08.2018 | Torque | - | Defensor Sporting | 0:0 | ||||
| 4. Jornada | 12.08.2018 | Defensor Sporting | - | Rampla Juniors | 2:2 | |
|||
| 5. Jornada | 19.08.2018 | Fénix | - | Defensor Sporting | 1:2 | ||||
| 7. Jornada | 02.09.2018 | Progreso | - | Defensor Sporting | 0:0 | ||||
| 9. Jornada | 16.09.2018 | Defensor Sporting | - | Racing | 2:1 | ||||
| 10. Jornada | 23.09.2018 | River Plate | - | Defensor Sporting | 3:2 | ||||
| 14. Jornada | 28.10.2018 | Boston River | - | Defensor Sporting | 3:1 |
Uruguay