| 1. Jornada | 19.02.2012 | Rampla Juniors | - | Defensor Sporting | 0:2 |  |
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| 2. Jornada | 26.02.2012 | Defensor Sporting | - | Nacional | 2:2 | |
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| 3. Jornada | 04.03.2012 | Cerrito | - | Defensor Sporting | 0:2 | ||||
| 5. Jornada | 24.03.2012 | Fénix | - | Defensor Sporting | 0:1 | ||||
| 6. Jornada | 01.04.2012 | Defensor Sporting | - | Liverpool | 4:2 | ||||
| 4. Jornada | 05.04.2012 | Defensor Sporting | - | Peñarol | 0:0 | |
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| 10. Jornada | 29.04.2012 | Defensor Sporting | - | Montevideo Wanderers | 2:1 | ||||
| 11. Jornada | 06.05.2012 | Danubio | - | Defensor Sporting | 0:1 | ||||
| 12. Jornada | 13.05.2012 | Defensor Sporting | - | Cerro Largo | 2:1 | ||||
| 7. Jornada | 16.05.2012 | Rentistas | - | Defensor Sporting | 0:2 | ||||
| 13. Jornada | 20.05.2012 | Bella Vista | - | Defensor Sporting | 0:1 |  |
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| 15. Jornada | 03.06.2012 | River Plate | - | Defensor Sporting | 2:1 |
Uruguay