| 2. Jornada | 12.09.2021 | AEK Larnaca | - | Omonia Nikosia | 2:1 | ||||
| 3. Jornada | 20.09.2021 | Omonia Nikosia | - | Doxa Katokopias | 2:1 | ||||
| 4. Jornada | 26.09.2021 | Omonia Nikosia | - | Paphos FC | 1:1 | ||||
| 5. Jornada | 03.10.2021 | Olympiacos Nikosia | - | Omonia Nikosia | 1:0 | ||||
| 6. Jornada | 17.10.2021 | Omonia Nikosia | - | Apollon Limassol | 1:0 | ||||
| 7. Jornada | 25.10.2021 | PAEEK | - | Omonia Nikosia | 1:0 | ||||
| 8. Jornada | 29.10.2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 |  |
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| 10. Jornada | 21.11.2021 | Omonia Nikosia | - | Aris Limassol | 3:0 | ||||
| 12. Jornada | 05.12.2021 | AEL Limassol | - | Omonia Nikosia | 0:1 | ||||
| 15. Jornada | 05.01.2022 | Paphos FC | - | Omonia Nikosia | 1:1 | ||||
| 22. Jornada | 25.02.2022 | Omonia Nikosia | - | APOEL Nikosia | 2:4 | |
Chipre