| 4. Jornada | 27.09.2021 | APOEL Nikosia | - | PAEEK | 1:0 | ||||
| 5. Jornada | 03.10.2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 |  |
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| 6. Jornada | 18.10.2021 | APOEL Nikosia | - | Ethnikos Achna | 2:1 | ||||
| 19. Jornada | 30.01.2022 | APOEL Nikosia | - | Doxa Katokopias | 2:0 | ||||
| 15. Jornada | 09.02.2022 | PAEEK | - | APOEL Nikosia | 1:3 | ||||
| 16. Jornada | 17.02.2022 | APOEL Nikosia | - | Anorthosis Famagusta | 0:2 | ||||
| 22. Jornada | 25.02.2022 | Omonia Nikosia | - | APOEL Nikosia | 2:4 |
Chipre