| 2. Jornada | 03.02.2023 | Tacuary | - | Guaireña FC | 1:2 |  |
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| 3. Jornada | 12.02.2023 | Guaireña FC | - | Sportivo Trinidense | 1:1 | |
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| 4. Jornada | 18.02.2023 | Guaireña FC | - | Cerro Porteño | 0:2 |  |
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| 5. Jornada | 27.02.2023 | Club Olimpia | - | Guaireña FC | 1:1 | ||||
| 6. Jornada | 03.03.2023 | Guaireña FC | - | General Caballero DJLM | 0:0 | ||||
| 7. Jornada | 11.03.2023 | Libertad | - | Guaireña FC | 2:0 | ||||
| 8. Jornada | 18.03.2023 | Guaireña FC | - | Sportivo Ameliano | 0:1 | ||||
| 9. Jornada | 24.03.2023 | Guaraní | - | Guaireña FC | 1:1 | ||||
| 10. Jornada | 02.04.2023 | Guaireña FC | - | Resistencia SC | 1:3 | |
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| 11. Jornada | 09.04.2023 | Sportivo Luqueño | - | Guaireña FC | 0:0 | ||||
| 12. Jornada | 12.04.2023 | Club Nacional | - | Guaireña FC | 2:2 | |
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| 13. Jornada | 15.04.2023 | Guaireña FC | - | Tacuary | 0:1 | ||||
| 16. Jornada | 08.05.2023 | Guaireña FC | - | Club Olimpia | 1:0 | ||||
| 18. Jornada | 17.05.2023 | Guaireña FC | - | Libertad | 0:2 |
Uruguay