| 1. Jornada | 13.01.2021 | Jicaral | - | AD San Carlos | 1:1 | ||||
| 2. Jornada | 18.01.2021 | AD San Carlos | - | CS Herediano | 2:1 | ||||
| 3. Jornada | 21.01.2021 | AD San Carlos | - | Guadalupe | 1:0 | ||||
| 4. Jornada | 24.01.2021 | LD Alajuelense | - | AD San Carlos | 1:1 | ||||
| 5. Jornada | 31.01.2021 | AD San Carlos | - | Sporting FC | 0:0 | ||||
| 6. Jornada | 04.02.2021 | AD San Carlos | - | CS Cartaginés | 1:1 | ||||
| 7. Jornada | 08.02.2021 | Santos de Guápiles | - | AD San Carlos | 3:1 | ||||
| 8. Jornada | 15.02.2021 | AD San Carlos | - | Municipal Grecia | 1:4 | ||||
| 9. Jornada | 21.02.2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 | ||||
| 10. Jornada | 01.03.2021 | AD San Carlos | - | Limón FC | 0:3 | ||||
| 11. Jornada | 04.03.2021 | Deportivo Saprissa | - | AD San Carlos | 1:1 | ||||
| 12. Jornada | 08.03.2021 | AD San Carlos | - | Jicaral | 0:0 | ||||
| 14. Jornada | 21.03.2021 | Guadalupe | - | AD San Carlos | 1:2 | ||||
| 16. Jornada | 05.04.2021 | Sporting FC | - | AD San Carlos | 2:0 | ||||
| 19. Jornada | 22.04.2021 | Municipal Grecia | - | AD San Carlos | 2:1 | ||||
| 20. Jornada | 27.04.2021 | AD San Carlos | - | Municipal Pérez Zeledón | 0:1 | ||||
| 22. Jornada | 13.05.2021 | AD San Carlos | - | Deportivo Saprissa | 2:0 |  |
Paraguay