| 4. Jornada | 14.08.2021 | Fortaleza FC | - | Leones FC | 3:1 | ||||
| 5. Jornada | 22.08.2021 | Llaneros FC | - | Fortaleza FC | 1:1 |  |
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| 6. Jornada | 28.08.2021 | Fortaleza FC | - | Tigres FC | 2:1 | ||||
| 7. Jornada | 05.09.2021 | Barranquilla FC | - | Fortaleza FC | 0:0 | ||||
| 8. Jornada | 15.09.2021 | Fortaleza FC | - | Bogotá FC | 3:0 | |
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| 9. Jornada | 19.09.2021 | Atlético FC | - | Fortaleza FC | 0:3 | |
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| 10. Jornada | 25.09.2021 | Fortaleza FC | - | Orsomarso SC | 4:0 | ||||
| 11. Jornada | 03.10.2021 | Valledupar FC | - | Fortaleza FC | 1:1 | ||||
| 12. Jornada | 13.10.2021 | Fortaleza FC | - | Boyacá Chicó | 0:0 | |
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| 14. Jornada | 24.10.2021 | Real Santander | - | Fortaleza FC | 1:1 |
Colombia