| 1. Jornada | 16.07.2021 | Sepsi OSK | - | Academica Clinceni | 2:0 | ||||
| 2. Jornada | 26.07.2021 | Chindia Târgoviște | - | Sepsi OSK | 1:1 | ||||
| 3. Jornada | 02.08.2021 | Sepsi OSK | - | CS Mioveni | 1:2 | ||||
| 5. Jornada | 15.08.2021 | Sepsi OSK | - | Argeș Pitești | 0:2 | ||||
| 6. Jornada | 23.08.2021 | FCSB | - | Sepsi OSK | 1:1 | ||||
| 7. Jornada | 29.08.2021 | Sepsi OSK | - | FC Botoşani | 1:1 | ||||
| 8. Jornada | 13.09.2021 | CS Universitatea Craiova | - | Sepsi OSK | 1:1 | ||||
| 9. Jornada | 19.09.2021 | Sepsi OSK | - | UTA Arad | 0:0 | ||||
| 10. Jornada | 27.09.2021 | Gaz Metan Mediaş | - | Sepsi OSK | 0:0 | ||||
| 11. Jornada | 02.10.2021 | Sepsi OSK | - | Rapid Bucureşti | 2:2 | ||||
| 12. Jornada | 16.10.2021 | Sepsi OSK | - | FC Voluntari | 1:2 |  |
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| 13. Jornada | 25.10.2021 | CFR Cluj | - | Sepsi OSK | 2:0 | ||||
| 15. Jornada | 06.11.2021 | FC Universitatea Craiova | - | Sepsi OSK | 1:1 |
Serbia