| 2. Jornada | 24.07.2021 | FC Voluntari | - | FC Botoşani | 0:1 |  |
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| 4. Jornada | 06.08.2021 | FC Botoşani | - | UTA Arad | 2:1 |  |
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| 5. Jornada | 16.08.2021 | Gaz Metan Mediaş | - | FC Botoşani | 0:1 | ||||
| 6. Jornada | 22.08.2021 | FC Botoşani | - | Rapid Bucureşti | 0:2 | ||||
| 8. Jornada | 11.09.2021 | FC Botoşani | - | CFR Cluj | 1:0 | ||||
| 12. Jornada | 18.10.2021 | FC Botoşani | - | Chindia Târgoviște | 0:0 | ||||
| 13. Jornada | 23.10.2021 | CS Mioveni | - | FC Botoşani | 1:1 | ||||
| 17. Jornada | 28.11.2021 | FC Botoşani | - | FC Voluntari | 1:1 | ||||
| 18. Jornada | 06.12.2021 | FC Botoşani | - | CS Universitatea Craiova | 2:2 |
Macedonia del Norte
Bulgaria