| 1. Jornada | 05.02.2022 | Montevideo City Torque | - | Cerro Largo | 1:1 | ||||
| 2. Jornada | 14.02.2022 | Montevideo Wanderers | - | Cerro Largo | 1:0 | ||||
| 3. Jornada | 19.02.2022 | Cerro Largo | - | Plaza Colonia | 0:5 | ||||
| 4. Jornada | 25.02.2022 | Boston River | - | Cerro Largo | 3:0 |  |
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| 5. Jornada | 05.03.2022 | River Plate | - | Cerro Largo | 1:1 | |
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| 6. Jornada | 22.03.2022 | Cerro Largo | - | Cerrito | 1:0 | ||||
| 7. Jornada | 03.04.2022 | Fénix | - | Cerro Largo | 2:0 | |
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| 8. Jornada | 09.04.2022 | Cerro Largo | - | Defensor Sporting | 0:0 | |
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| 9. Jornada | 16.04.2022 | Albion | - | Cerro Largo | 2:1 | ||||
| 10. Jornada | 23.04.2022 | Cerro Largo | - | Nacional | 0:2 | ||||
| 11. Jornada | 08.05.2022 | Danubio | - | Cerro Largo | 2:0 | ||||
| 12. Jornada | 15.05.2022 | Cerro Largo | - | Deportivo Maldonado | 1:0 | ||||
| 13. Jornada | 21.05.2022 | Rentistas | - | Cerro Largo | 2:0 | ||||
| 14. Jornada | 28.05.2022 | Cerro Largo | - | Liverpool | 1:2 |
Uruguay