| 3. Jornada | 13.08.2022 | Plaza Colonia | - | Cerro Largo | 2:0 |  |
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| 5. Jornada | 29.08.2022 | Cerro Largo | - | River Plate | 0:5 | ||||
| 4. Jornada | 04.09.2022 | Cerro Largo | - | Boston River | 1:1 | ||||
| 7. Jornada | 11.09.2022 | Cerro Largo | - | Fénix | 1:0 | ||||
| 8. Jornada | 16.09.2022 | Defensor Sporting | - | Cerro Largo | 0:1 | |
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| 9. Jornada | 18.09.2022 | Cerro Largo | - | Albion | 1:2 | |
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| 10. Jornada | 25.09.2022 | Nacional | - | Cerro Largo | 1:1 | ||||
| 11. Jornada | 30.09.2022 | Cerro Largo | - | Danubio | 1:0 | |
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| 12. Jornada | 07.10.2022 | Deportivo Maldonado | - | Cerro Largo | 0:1 | ||||
| 13. Jornada | 11.10.2022 | Cerro Largo | - | Rentistas | 2:1 | ||||
| 14. Jornada | 16.10.2022 | Liverpool | - | Cerro Largo | 1:0 | |
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| 15. Jornada | 23.10.2022 | Cerro Largo | - | Peñarol | 0:2 |
Uruguay