| 6. Jornada | 22.02.2025 | San Francisco FC | - | Tauro FC | 1:1 | ||||
| 7. Jornada | 26.02.2025 | San Francisco FC | - | Plaza Amador | 0:1 | ||||
| 10. Jornada | 23.03.2025 | Árabe Unido | - | San Francisco FC | 1:3 | ||||
| 11. Jornada | 29.03.2025 | San Francisco FC | - | Alianza | 1:2 | ||||
| 12. Jornada | 05.04.2025 | San Francisco FC | - | Veraguas United | 4:0 | ||||
| 13. Jornada | 12.04.2025 | San Francisco FC | - | Herrera FC | 1:1 |  |
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| 16. Jornada | 10.05.2025 | San Francisco FC | - | UD Universitario | 3:0 |
Panamá