| 13. Jornada | 27.09.2021 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 3:0 | ||||
| 14. Jornada | 03.10.2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 |  |
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| 15. Jornada | 13.10.2021 | Municipal Pérez Zeledón | - | CS Herediano | 0:1 | ||||
| 16. Jornada | 17.10.2021 | Guadalupe | - | Municipal Pérez Zeledón | 0:1 | |
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| 17. Jornada | 23.10.2021 | Municipal Pérez Zeledón | - | Municipal Grecia | 3:1 | ||||
| 18. Jornada | 28.10.2021 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:0 | ||||
| 19. Jornada | 31.10.2021 | Santos de Guápiles | - | Municipal Pérez Zeledón | 3:2 | |
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| 21. Jornada | 24.11.2021 | Municipal Pérez Zeledón | - | Sporting FC | 1:0 | ||||
| 22. Jornada | 28.11.2021 | LD Alajuelense | - | Municipal Pérez Zeledón | 3:0 |
Costa Rica