| 4. Jornada | 06.02.2022 | Gallos Blancos [Sub 20] | - | Puebla FC [Sub 20] | 0:2 |  |
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| 5. Jornada | 11.02.2022 | Puebla FC [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:2 | ||||
| 6. Jornada | 18.02.2022 | Puebla FC [Sub 20] | - | CF Monterrey [Sub 20] | 3:0 | ||||
| 7. Jornada | 26.02.2022 | Deportivo Guadalajara [Sub 20] | - | Puebla FC [Sub 20] | 2:0 | ||||
| 8. Jornada | 01.03.2022 | Puebla FC [Sub 20] | - | FC Juárez [Sub 20] | 2:2 | ||||
| 9. Jornada | 05.03.2022 | Cruz Azul [Sub 20] | - | Puebla FC [Sub 20] | 3:0 | ||||
| 11. Jornada | 18.03.2022 | Puebla FC [Sub 20] | - | Santos Laguna [Sub 20] | 0:1 | ||||
| 16. Jornada | 22.04.2022 | Puebla FC [Sub 20] | - | Club Necaxa [Sub 20] | 1:3 |  |
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| 17. Jornada | 29.04.2022 | Mazatlán FC [Sub 20] | - | Puebla FC [Sub 20] | 4:1 | |
México