| 3. Jornada | 14.08.2021 | Marathón | - | Motagua | 2:0 | ||||
| 5. Jornada | 27.08.2021 | Platense | - | Marathón | 3:1 | ||||
| 9. Jornada | 16.09.2021 | Marathón | - | Olimpia | 3:1 |  |
|||
| 10. Jornada | 20.09.2021 | Real España | - | Marathón | 0:1 |  |
|||
| 11. Jornada | 25.09.2021 | Marathón | - | Vida | 1:2 | |
|||
| 13. Jornada | 09.10.2021 | Marathón | - | Honduras Progreso | 2:1 | |
|||
| 17. Jornada | 30.10.2021 | Marathón | - | Victoria | 0:0 | |
|||
| 18. Jornada | 10.11.2021 | Real Sociedad | - | Marathón | 0:3 |
Honduras