| 3. Jornada | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 | ||||
| 4. Jornada | 04.02.2021 | Montevideo City Torque | - | Defensor Sporting | 0:0 | ||||
| 7. Jornada | 15.02.2021 | Defensor Sporting | - | Fénix | 2:2 |  |
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| 8. Jornada | 18.02.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 9. Jornada | 20.02.2021 | Defensor Sporting | - | Liverpool | 0:3 | ||||
| 10. Jornada | 28.02.2021 | Defensor Sporting | - | Danubio | 1:1 |  |
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| 15. Jornada | 29.03.2021 | Cerro Largo | - | Defensor Sporting | 0:0 |
Uruguay