| 2. Jornada | 01.08.2021 | Bogotá FC | - | Barranquilla FC | 2:0 | ||||
| 4. Jornada | 16.08.2021 | Orsomarso SC | - | Barranquilla FC | 0:0 | ||||
| 6. Jornada | 01.09.2021 | Boyacá Chicó | - | Barranquilla FC | 1:1 |  |
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| 8. Jornada | 11.09.2021 | Real Santander | - | Barranquilla FC | 1:1 | |
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| 9. Jornada | 19.09.2021 | Barranquilla FC | - | Cortuluá | 2:2 | ||||
| 11. Jornada | 03.10.2021 | Barranquilla FC | - | Boca Juniors de Cali | 1:0 | ||||
| 12. Jornada | 12.10.2021 | Real Cartagena | - | Barranquilla FC | 3:1 | ||||
| 14. Jornada | 24.10.2021 | Llaneros FC | - | Barranquilla FC | 4:2 |
Colombia