| 2. Jornada | 07.08.2021 | Atlético Marte | - | AD Chalatenango | 0:2 | ||||
| 3. Jornada | 11.08.2021 | AD Chalatenango | - | Alianza | 2:1 | ||||
| 4. Jornada | 15.08.2021 | Santa Tecla FC | - | AD Chalatenango | 1:1 | ||||
| 5. Jornada | 22.08.2021 | AD Chalatenango | - | Luis Ángel Firpo | 0:2 | ||||
| 6. Jornada | 26.08.2021 | CD Águila | - | AD Chalatenango | 2:1 | ||||
| 7. Jornada | 29.08.2021 | AD Chalatenango | - | Once Municipal | 1:2 | ||||
| 8. Jornada | 11.09.2021 | Jocoro FC | - | AD Chalatenango | 3:1 | ||||
| 9. Jornada | 16.09.2021 | AD Chalatenango | - | FAS | 1:2 | ||||
| 12. Jornada | 02.10.2021 | Platense Zacatecoluca | - | AD Chalatenango | 2:1 |  |
|||
| 14. Jornada | 21.10.2021 | Alianza | - | AD Chalatenango | 1:0 | ||||
| 15. Jornada | 24.10.2021 | AD Chalatenango | - | Santa Tecla FC | 0:2 | ||||
| 16. Jornada | 31.10.2021 | Luis Ángel Firpo | - | AD Chalatenango | 4:2 |
Estados Unidos