| 1. Jornada | 26.07.2021 | Unión Magdalena | - | Fortaleza FC | 3:1 | ||||
| 2. Jornada | 31.07.2021 | Real Santander | - | Unión Magdalena | 3:3 |  |
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| 3. Jornada | 10.08.2021 | Unión Magdalena | - | Cortuluá | 2:0 |  |
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| 5. Jornada | 21.08.2021 | Boca Juniors de Cali | - | Unión Magdalena | 0:2 | |
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| 6. Jornada | 31.08.2021 | Unión Magdalena | - | Real Cartagena | 1:0 | ||||
| 7. Jornada | 04.09.2021 | Leones FC | - | Unión Magdalena | 3:0 | ||||
| 8. Jornada | 12.09.2021 | Unión Magdalena | - | Llaneros FC | 1:1 | ||||
| 9. Jornada | 22.09.2021 | Tigres FC | - | Unión Magdalena | 0:0 | ||||
| 10. Jornada | 26.09.2021 | Unión Magdalena | - | Barranquilla FC | 3:0 | |
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| 11. Jornada | 01.10.2021 | Bogotá FC | - | Unión Magdalena | 3:1 | ||||
| 12. Jornada | 09.10.2021 | Unión Magdalena | - | Atlético FC | 3:3 | |
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| 13. Jornada | 18.10.2021 | Orsomarso SC | - | Unión Magdalena | 1:2 | |
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| 14. Jornada | 24.10.2021 | Unión Magdalena | - | Valledupar FC | 3:1 | |
Colombia