| 1. Jornada | 27.07.2008 | Club San Luis | - | Monarcas Morelia | 2:2 | ||||
| 2. Jornada | 03.08.2008 | CF Pachuca | - | Club San Luis | 2:3 | ||||
| 6. Jornada | 07.08.2008 | Club San Luis | - | Cruz Azul | 2:1 | ||||
| 3. Jornada | 10.08.2008 | Club San Luis | - | Jaguares Chiapas | 2:0 | ||||
| 4. Jornada | 17.08.2008 | Atlas Guadalajara | - | Club San Luis | 0:1 | ||||
| 7. Jornada | 31.08.2008 | Atlante | - | Club San Luis | 1:0 | ||||
| 9. Jornada | 21.09.2008 | Pumas UNAM | - | Club San Luis | 0:1 |  |
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| 10. Jornada | 28.09.2008 | Club San Luis | - | Puebla FC | 1:1 |  |
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| 11. Jornada | 05.10.2008 | Indios Juárez | - | Club San Luis | 2:3 | ||||
| 12. Jornada | 12.10.2008 | Club San Luis | - | Deportivo Guadalajara | 0:0 | ||||
| 13. Jornada | 18.10.2008 | UAG Tecos | - | Club San Luis | 5:2 | ||||
| 14. Jornada | 26.10.2008 | Club San Luis | - | CF Monterrey | 2:0 | ||||
| 15. Jornada | 02.11.2008 | Club Necaxa | - | Club San Luis | 1:1 |
México