| 1. Jornada | 30.07.2022 | Plaza Colonia | - | Boston River | 1:1 | ||||
| 2. Jornada | 06.08.2022 | River Plate | - | Plaza Colonia | 2:0 | ||||
| 3. Jornada | 13.08.2022 | Plaza Colonia | - | Cerro Largo | 2:0 | ||||
| 6. Jornada | 22.08.2022 | Albion | - | Plaza Colonia | 1:0 |  |
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| 8. Jornada | 13.09.2022 | Danubio | - | Plaza Colonia | 1:1 | ||||
| 9. Jornada | 17.09.2022 | Plaza Colonia | - | Deportivo Maldonado | 0:1 | ||||
| 11. Jornada | 01.10.2022 | Plaza Colonia | - | Liverpool | 1:3 | ||||
| 12. Jornada | 10.10.2022 | Peñarol | - | Plaza Colonia | 0:1 | ||||
| 14. Jornada | 17.10.2022 | Montevideo Wanderers | - | Plaza Colonia | 2:1 | |
Guatemala