| 3. Jornada | 16.06.2021 | Villa Teresa | - | Rampla Juniors | 0:1 | ||||
| 4. Jornada | 25.06.2021 | Rampla Juniors | - | Juventud de Las Piedras | 0:2 | ||||
| 5. Jornada | 02.07.2021 | Uruguay Montevideo | - | Rampla Juniors | 2:0 | ||||
| 9. Jornada | 31.07.2021 | Rampla Juniors | - | CA Cerro | 0:1 | ||||
| 10. Jornada | 05.08.2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 11. Jornada | 12.08.2021 | Rampla Juniors | - | Central Español | 2:1 | ||||
| 12. Jornada | 15.09.2021 | Rampla Juniors | - | Atenas | 2:1 | ||||
| 13. Jornada | 22.09.2021 | Racing | - | Rampla Juniors | 2:0 | ||||
| 16. Jornada | 13.10.2021 | Rampla Juniors | - | Uruguay Montevideo | 1:1 | ||||
| 17. Jornada | 19.10.2021 | Albion | - | Rampla Juniors | 2:0 | ||||
| 18. Jornada | 28.10.2021 | Danubio | - | Rampla Juniors | 2:0 |  |
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| 21. Jornada | 18.11.2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | ||||
| 22. Jornada | 25.11.2021 | Central Español | - | Rampla Juniors | 3:0 |
Uruguay