| 1. Jornada | 01.08.2021 | Real Estelí FC | - | H&H Export Sébaco | 4:0 | ||||
| 2. Jornada | 10.08.2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 | ||||
| 3. Jornada | 15.08.2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
| 6. Jornada | 03.09.2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
| 7. Jornada | 12.09.2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 | ||||
| 9. Jornada | 26.09.2021 | Real Madriz | - | H&H Export Sébaco | 3:3 | ||||
| 10. Jornada | 02.10.2021 | H&H Export Sébaco | - | Real Estelí FC | 1:3 | ||||
| 14. Jornada | 23.10.2021 | H&H Export Sébaco | - | Juventus Managua | 3:3 | ||||
| 16. Jornada | 04.11.2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 |
Nicaragua