| 4. Jornada | 23.07.2022 | Club Tijuana [Sub 20] | - | CF América [Sub 20] | 3:3 |  |
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| 9. Jornada | 17.08.2022 | CF Pachuca [Sub 20] | - | CF América [Sub 20] | 0:0 | ||||
| 13. Jornada | 06.09.2022 | CF América [Sub 20] | - | Atlético San Luis [Sub 20] | 5:0 | |
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| 5. Jornada | 14.09.2022 | CF América [Sub 20] | - | Santos Laguna [Sub 20] | 1:0 |  |
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| 15. Jornada | 17.09.2022 | CF América [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 2:2 | |
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| 17. Jornada | 30.09.2022 | Puebla FC [Sub 20] | - | CF América [Sub 20] | 1:1 | |
México