| 8. Jornada | 12.09.2021 | Municipal Limeño | - | CD Águila | 1:0 | ||||
| 9. Jornada | 15.09.2021 | Jocoro FC | - | Municipal Limeño | 3:1 | ||||
| 12. Jornada | 02.10.2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 14. Jornada | 09.10.2021 | Municipal Limeño | - | Once Municipal | 1:1 |  |
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| 16. Jornada | 30.10.2021 | Municipal Limeño | - | Isidro Metapán | 2:2 |  |
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| 17. Jornada | 02.11.2021 | Atlético Marte | - | Municipal Limeño | 2:0 | ||||
| 18. Jornada | 07.11.2021 | Municipal Limeño | - | Santa Tecla FC | 1:1 | ||||
| 19. Jornada | 14.11.2021 | CD Águila | - | Municipal Limeño | 2:1 | ||||
| 20. Jornada | 17.11.2021 | Municipal Limeño | - | Jocoro FC | 0:0 | ||||
| 21. Jornada | 21.11.2021 | Municipal Limeño | - | AD Chalatenango | 0:3 | ||||
| 22. Jornada | 27.11.2021 | Platense Zacatecoluca | - | Municipal Limeño | 0:1 |
El Salvador