| 2. Jornada | 23.01.2022 | Victoria | - | Real Sociedad | 2:0 |  |
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| 3. Jornada | 06.02.2022 | Real Sociedad | - | Lobos UPNFM | 2:2 | |
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| 4. Jornada | 10.02.2022 | Real Sociedad | - | Honduras Progreso | 4:2 | ||||
| 5. Jornada | 14.02.2022 | Real España | - | Real Sociedad | 4:1 | ||||
| 6. Jornada | 20.02.2022 | Real Sociedad | - | Platense | 1:1 | |
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| 7. Jornada | 27.02.2022 | Real Sociedad | - | Marathón | 1:0 | ||||
| 8. Jornada | 03.03.2022 | Vida | - | Real Sociedad | 4:0 | ||||
| 9. Jornada | 06.03.2022 | Real Sociedad | - | Motagua | 2:1 | ||||
| 10. Jornada | 13.03.2022 | Lobos UPNFM | - | Real Sociedad | 1:0 | |
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| 17. Jornada | 25.04.2022 | Marathón | - | Real Sociedad | 6:0 | ||||
| 18. Jornada | 01.05.2022 | Motagua | - | Real Sociedad | 6:0 | |
Honduras