| 1. Jornada | 20.01.2022 | Olimpia | - | Real Sociedad | 4:2 |  |
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| 2. Jornada | 23.01.2022 | Victoria | - | Real Sociedad | 2:0 | ||||
| 4. Jornada | 10.02.2022 | Real Sociedad | - | Honduras Progreso | 4:2 | ||||
| 9. Jornada | 06.03.2022 | Real Sociedad | - | Motagua | 2:1 |  |
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| 10. Jornada | 13.03.2022 | Lobos UPNFM | - | Real Sociedad | 1:0 | ||||
| 12. Jornada | 03.04.2022 | Honduras Progreso | - | Real Sociedad | 0:1 | ||||
| 14. Jornada | 11.04.2022 | Platense | - | Real Sociedad | 1:0 | ||||
| 16. Jornada | 21.04.2022 | Real Sociedad | - | Olimpia | 0:1 |
Honduras