| 1. Jornada | 28.07.2021 | Real Cartagena | - | Valledupar FC | 2:2 |  |
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| 2. Jornada | 31.07.2021 | Valledupar FC | - | Leones FC | 1:1 | ||||
| 3. Jornada | 09.08.2021 | Llaneros FC | - | Valledupar FC | 1:0 | ||||
| 4. Jornada | 15.08.2021 | Valledupar FC | - | Tigres FC | 0:0 | ||||
| 5. Jornada | 26.08.2021 | Barranquilla FC | - | Valledupar FC | 2:1 | |
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| 6. Jornada | 30.08.2021 | Valledupar FC | - | Bogotá FC | 0:2 | ||||
| 7. Jornada | 06.09.2021 | Atlético FC | - | Valledupar FC | 3:2 |  |
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| 8. Jornada | 11.09.2021 | Valledupar FC | - | Orsomarso SC | 1:2 | ||||
| 10. Jornada | 28.09.2021 | Boyacá Chicó | - | Valledupar FC | 2:0 | |
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| 11. Jornada | 03.10.2021 | Valledupar FC | - | Fortaleza FC | 1:1 | |
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| 13. Jornada | 19.10.2021 | Valledupar FC | - | Cortuluá | 1:2 | |
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| 14. Jornada | 24.10.2021 | Unión Magdalena | - | Valledupar FC | 3:1 | |
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| 15. Jornada | 30.10.2021 | Valledupar FC | - | Boca Juniors de Cali | 2:1 |
Colombia